UV Spectrophotometric method has been developed for simultaneous estimation of Cefpodoxime proxetil (CPD) and Levofloxacin hemihydrate (LVX) in bulk drug and in pharmaceutical formulation. This method utilizes methanol as a solvent and λmax of Cefpodoxime proxetil and Levofloxacin hemihydrate selected for analysis were found to be 235 nm and 300 nm respectively. Linearity was observed in the concentration range of 2-10 μg/ml for Cefpodoxime proxetil and 2.5-10.5 μg/ml for Levofloxacin hemihydrate. The method was validated statistically and by recovery studies. The mean % recovery was 99.03–100.63 % and 99.56–100.27 % for Cefpodoxime proxetil and Levofloxacin hemihydrate respectively. Amounts of drug estimated from tablet formulation were in good agreement with label claim. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate and sensitive. Hence, can be used for quality control of combined pharmaceutical dosage forms.
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